Hemoglobin Siam α2 15argβ2: A new α-chain variant

ชื่อเรื่อง

Hemoglobin Siam α2 15argβ2: A new α-chain variant See all items with this value

ผู้สร้าง/เจ้าของผลงาน

Pootrakul, Sa-nga See all items with this value

Srichiyanont, Sithichai See all items with this value

Wasi, Prawase See all items with this value

Suanpan, Suparb See all items with this value

หัวเรื่อง

Genetics (clinical) See all items with this value

Genetics See all items with this value

บทคัดย่อ

A 28-year-old, healthy male of chinese ancestry with normal hematologic findings was found to have an abnormal hemoglobin moving more slowly than hemoglobin F in starch gel electrophoresis. The relative amounts of the abnormal component, hemoglobin A2 and slow hemoglobin A2, as determined by cellulose acetate electrophoresis, were 15.2, 1.64, and 0.56% respectively. The hemoglobin chain dissociation by p-chloromercuribenzoate treatment confirmed that it was an α-chain variant. The abnormal globin chain was fractionated by carboxymethyl cellulose chromatography. Peptide mapping revealed that the amino acid alteration occurs in αTp III (tryptic peptide No. 3, residues 12 to 16 of the α-chain). Special stains and amino acid analyses of the abnormal peptide indicated that glycine at residue 15 was replaced by arginine, and the hemoglobin is thus α2 15argβ2. Since the mutation has not been previously described, it is proposed that it be called “Hemoglobin Siam”.

ผู้ร่วมงาน

Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand See all items with this value

Nutrition Division, Department of Public Health Promotion, Ministry of Public Health, Bangkok, Thailand See all items with this value

ปีที่ผลิตเอกสาร

1974 See all items with this value

วันที่บันทึกข้อมูล

2023-05-01

ประเภท

Article See all items with this value

รูปแบบ

pdf See all items with this value

ขนาดหรือจำนวนของเอกสาร

6 pages

ต้นฉบับ/แหล่งที่มาของเอกสาร

Humangenetik, Vol, 23, Page 199–204

ภาษา

en See all items with this value

รหัส หรือตัวบ่งชี้เอกสาร

https://doi.org/10.1007/BF00285105 See all items with this value

ขอบเขต

Health See all items with this value

เจ้าของลิขสิทธิ์

Springer Nature Switzerland AG. Part of Springer Nature. See all items with this value

Collections

สุขภาพ

การศึกษา

Hemoglobin Siam α2 15argβ2 A new α-chain variant.jpg

New Tags

Position: 125 (23 views)