β-Thalassemia in Thailand
ชื่อเรื่อง
β-Thalassemia in Thailand
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ผู้สร้าง/เจ้าของผลงาน
Winichagoon, Pranee
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Fucharoen, Suthat
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Thonglairoam, Varaporn
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Tanapotiwirut, Veerawan
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Wasi, Prawase
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หัวเรื่อง
History and Philosophy of Science
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General Biochemistry, Genetics and Molecular Biology
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General Neuroscience
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คำอธิบายรายละเอียดของเอกสาร
This study was supported by U.S. Public Health Research Grant HL 34408 from the National Heart, Lung, and Blood Institute and CEC grant, Program Contract No. TS2.0131.TH(H).
บทคัดย่อ
P-Thalassemia and hemoglobin (Hb) E are prevalent in Thailand. The frequencies of p-thalassemia vary from 3% in central Thailand to 9% in the north. The frequency of Hb E is 13% on the average; and its distribution is heterogeneous, attaining 50-60% at the junction with Laos and Cambodia.14 Po-thalassemia is much more common than P + -thalassemia. Homozygous Po-thalassemia and double heterozygosity between Po- and P' thalassemia as a rule result in severe Cooley's anemia disease. While the Hb E homozygote is asymptomatic, double heterozygosity between P"-thalassemia and Hb E (p"-thalassemia/Hb E) can be a very severe disease; a spectrum of severity with hemoglobin levels ranging from 3 to 13 g/dl has been observed.' Po-Thalassemia/Hb E is the most common p-thalassemic disease in Southeast Asia.
At present there are more than 70 different mutations resulting in P-thalassemia, most of which are single base changes in and around the p-globin gene. It has been found that, in general, P-thalassemia mutations are relatively population specific, i.e., each ethnic group has its own set of common mutants. The purpose of this paper is to review the nature of the molecular defects of P-thalassemia in Thailand and also to compare the patterns with those in neighboring countries.
At present there are more than 70 different mutations resulting in P-thalassemia, most of which are single base changes in and around the p-globin gene. It has been found that, in general, P-thalassemia mutations are relatively population specific, i.e., each ethnic group has its own set of common mutants. The purpose of this paper is to review the nature of the molecular defects of P-thalassemia in Thailand and also to compare the patterns with those in neighboring countries.
ผู้ร่วมงาน
Thalassemia Center Division of Hematology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Institute of Sciences and Technology for Development, Mahidol University, Bangkok, Thailand
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Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-05-02
ประเภท
Article
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รูปแบบ
ขนาดหรือจำนวนของเอกสาร
12 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
Annals of the New York Academy of Sciences ; volume 612, issue 1 Sixth Cooley, page 31-42
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รหัส หรือตัวบ่งชี้เอกสาร
ขอบเขต
เจ้าของลิขสิทธิ์
John Wiley & Sons, Inc.
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