The effect of erythroid hyperplasia on iron balance

ชื่อเรื่อง

The effect of erythroid hyperplasia on iron balance
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ผู้สร้าง/เจ้าของผลงาน

Pootrakul, Pensri
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Kitcharoen, Kriengkrai
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Yansukon, Pornpan
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Wasi, Prawase
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Fucharoen, Suthat
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Charoenlarp, Preecha
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Brittenham, Gary
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Pippard, Martin J.
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Finch, Clement A. See all items with this value

หัวเรื่อง

Thalassemia See all items with this value

คำอธิบายรายละเอียดของเอกสาร

Supported by US Public Health Research Grant HL 34408 from the National Heart, Lung, and Blood Institute; National lnstitutes of Health Research Grant No. HL06242; a Travel Grant from
Welcome Trust, London; and the International Atomic Energy
Agency Fellowship Program of the National Research Council, National Academy of Sciences.

บทคัดย่อ

Measurements of erythropoiesis and iron balance were made in eight normal and 32 anemic subjects. The latter consisted of 12 individuals with ineffective erythropoiesis (beta-thalassemia/hemoglobin E), 13 subjects with ineffective erythropoiesis and hemolytic anemia (hemoglobin H), and seven subjects with hemolytic anemia (hereditary spherocytosis). A consistent relationship within each group existed between the degree of erythropoiesis and radioiron absorption. Although the effect of erythropoiesis on iron absorption was of similar magnitude in the two thalassemia groups, the effect in hereditary spherocytosis was much less. There was agreement between absorption and ferritin or magnetic susceptibility (SQUID) measurements of iron stores in thalassemia, but in hereditary spherocytosis a discrepancy existed between absorption and ferritin. It is concluded that, although increased erythropoiesis is associated with increased iron absorption, some additional factor associated with red cell breakdown is more directly responsible for the positive iron balance in thalassemia.

ผู้ร่วมงาน

Division of Hematology. Department of Medicine, Siriraj Hospital, Mahidol University
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Cleveland Metropolitan General Hospital
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Section of Haematology, Medical Research Council Clinical Research Center and Northwick Park Hospital, Harrow, Middlesex, England See all items with this value

Division of Hematology, Department of Medicine, University of Washington, Seattle
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ปีที่ผลิตเอกสาร

1988 See all items with this value

วันที่บันทึกข้อมูล

2023-05-02

ประเภท

Article See all items with this value

รูปแบบ

pdf See all items with this value

ขนาดหรือจำนวนของเอกสาร

6 pages

ต้นฉบับ/แหล่งที่มาของเอกสาร

Blood April, Vol. 71, No. 4, Page 1124-1129

ภาษา

en See all items with this value

รหัส หรือตัวบ่งชี้เอกสาร

https://doi.org/10.1182/blood.V71.4.1124.1124 See all items with this value

ขอบเขต

Health See all items with this value

เจ้าของลิขสิทธิ์

American Society of Hematology See all items with this value

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