Thalassemia in Southeast Asia: Determination of Different Degrees of Severity of Anemia in Thalassemia

ชื่อเรื่อง

Thalassemia in Southeast Asia: Determination of Different Degrees of Severity of Anemia in Thalassemia See all items with this value

ผู้สร้าง/เจ้าของผลงาน

Wasi, Prawase
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Pootrakul, Pensri
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Fucharoen, Suthat
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Winichagoon, Pranee
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Wilairat, Prapon
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Promboon, Amornrat See all items with this value

หัวเรื่อง

History and Philosophy of Science See all items with this value

General Biochemistry, Genetics and Molecular Biology See all items with this value

General Neuroscience See all items with this value

คำอธิบายรายละเอียดของเอกสาร

This study was supported by US Public Health research grant AM 09805 from the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases.

บทคัดย่อ

In Southeast Asia, a-thalassemias, P-thalassemia, hemoglobin (Hb) E and Hb Constant Spring are prevalent.'-3 The a-thalassemias consist of two common alleles, that is, a-thalassemia 1 occurring from deletion of two adjacent structural a-globin genes and a-thalassemia 2 occurring from DNA defects equivalent to deletion of one a-globin gene. The combined frequencies of a-thalassemia 1 and a-thalassemia 2 are 20-30 percent. p-thalassemia predominates over P+-thalassemia by a wide margin, and its frequencies vary from 3 to 9 percent. Hb E is frequent up to 50-60 percent in certain areas. Hb Constant Spring frequencies vary from a few percentage points to 8 percent. These genes form complex thalassemia syndromes.

ผู้ร่วมงาน

Mahidol University Faculty of Medicine, Siriraj Hospital See all items with this value

ปีที่ผลิตเอกสาร

1985 See all items with this value

วันที่บันทึกข้อมูล

2023-05-02

ประเภท

Article See all items with this value

รูปแบบ

pdf See all items with this value

ขนาดหรือจำนวนของเอกสาร

8 pages

ต้นฉบับ/แหล่งที่มาของเอกสาร

Annals of the New York Academy of Sciences ; volume 445, issue 1 Fifth Cooley, page 119-126

ภาษา

en See all items with this value

รหัส หรือตัวบ่งชี้เอกสาร

https://doi.org/10.1111/j.1749-6632.1985.tb17181.x See all items with this value

ขอบเขต

Health See all items with this value

เจ้าของลิขสิทธิ์

John Wiley & Sons, Inc. See all items with this value

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