Concomitant inheritance of α-thalassemia in β°-thalassemia/hb e disease

ชื่อเรื่อง

Concomitant inheritance of α-thalassemia in β°-thalassemia/hb e disease See all items with this value

ผู้สร้าง/เจ้าของผลงาน

Winichagoon, Pranee
See all items with this value

Fucharoen, Suthat
See all items with this value

Weatherall, David
See all items with this value

Wasi, Prawase See all items with this value

หัวเรื่อง

Hematology See all items with this value

คำอธิบายรายละเอียดของเอกสาร

This study was supported by a US. Public Health Service research grant AM
09805 from the National Institute of Arthritis, Diabetes, Digestive and Kidney
Diseases.

บทคัดย่อ

Concomitant inheritance of α-thalassemia in patients with β°-thalassemia/hemoglobin (Hb) E disease was detected by restriction endonuclease DNA mapping. Among 42 patients with β°-thalassemia/Hb E disease, seven were found to have an α-thalassemia-2 haplotype. Of these, five belonged to the rightward or 3.7-kb type of α-thalassemia-2 and the remaining two the leftward or 4.2-kb type. All the seven patients with α-thalassemia-2 haplotype had hemoglobin levels of 7.4 g/dl or above; those without detectable α-thalassemia had hemoglobin levels both higher and lower than 7.4 g/dI. The latter attended the clinic regularly, the former did occasionally. These findings suggest that concomitant inheritance of α-thalassemia can alleviate the severity of β°-thalassemia/Hb E disease. Failure to find α-thalassemia-1 haplotype in these patients suggests that concomitant inheritance of α-thalassemia-1 with β°-thalassemia/Hb E might lead to so mild a condition that the individuals do not present clinically. The fact that many patients without a detectable α-thalassemia haplotype also had hemoglobin levels of 7.4 g/dl or higher suggests that there are additional factors responsible for the mildness of β°-thalassemia/Hb E disease.

ผู้ร่วมงาน

Department of Medicine, Faculty of Medicine, Siriraj Hospital See all items with this value

The Thalassemia Center, Faculty of Graduate Studies, Mahidol University, Bangkok, Thailand See all items with this value

MRC Molecular Hematology Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, England See all items with this value

ปีที่ผลิตเอกสาร

1985 See all items with this value

วันที่บันทึกข้อมูล

2023-05-02

ประเภท

Article See all items with this value

รูปแบบ

pdf See all items with this value

ขนาดหรือจำนวนของเอกสาร

6 pages

ต้นฉบับ/แหล่งที่มาของเอกสาร

American Journal of Hematology ; volume 20, issue 3, page 217-222

ภาษา

en See all items with this value

รหัส หรือตัวบ่งชี้เอกสาร

https://doi.org/10.1002/ajh.2830200303 See all items with this value

ขอบเขต

Health See all items with this value

เจ้าของลิขสิทธิ์

John Wiley & Sons, Inc. See all items with this value

Collections

สุขภาพ

Concomitant inheritance of α-thalassemia in β°-thalassemiahb e disease.jpg

New Tags

Position: 256 (17 views)