Increased Red Blood Cell Protoporphyrin in Thalassemia: A Result of Relative Iron Deficiency
ชื่อเรื่อง
Increased Red Blood Cell Protoporphyrin in Thalassemia: A Result of Relative Iron Deficiency
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ผู้สร้าง/เจ้าของผลงาน
Pootrakul, Pensri
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Wattanasaree, Jittaporn
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Anuwatanakulchai, Manasaree
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Wasi, Prawase
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หัวเรื่อง
General Medicine
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Thalassemia
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บทคัดย่อ
Erythrocyte protoporphyrin (EP) was measured in 50 normal control subjects, 22 iron-responsive anemic subjects, and in 106 patients with thalassémie diseases. All normal subjects had EP of less than 80 μg/dL red blood cells, whereas all iron-deficiency subjects had EP of more than 80 μg/dL red blood cells. Six of 22 heterozygotes for thalassemias had elevated EP, and all of these had transferrin iron saturation of less than 16%, reflecting a complicating iron deficiency. Among 52 patients with β-thalassemia/hemoglobin (Hb) E disease, 26.9% had elevated EP levels, and among 32 patients with Hb H disease, 40.6% had elevated EP. These elevated EP levels were associated with transferrin iron saturation between 18 and 44%. In none of the thalassemie patients with transferrin iron saturation above 44% was EP elevated. These findings suggest that elevation of EP in some thalassemie patients causally is related to iron supply inadequate for the massively expanded erythropoiesis. This relative iron deficiency in thalassemia occurs at a transferrin iron saturation level usually considered to be normal. These relationships demonstrate the need for an increased iron supply in patients with erythroid marrow hyperplasia, if erythropoiesis is to proceed at maximal rates.
ผู้ร่วมงาน
The Thalassemia Center, Faculty of Graduate Studies and Division of Hematology
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Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-05-02
ประเภท
Article
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รูปแบบ
ขนาดหรือจำนวนของเอกสาร
5 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
American Journal of Clinical Pathology ; volume 82, issue 3, page 289-293
ภาษา
รหัส หรือตัวบ่งชี้เอกสาร
ขอบเขต
เจ้าของลิขสิทธิ์
Oxford University Press
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