Determination for different severity of anemia in thalassemia: Concordance and discordance among sib pairs
ชื่อเรื่อง
Determination for different severity of anemia in thalassemia: Concordance and discordance among sib pairs
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ผู้สร้าง/เจ้าของผลงาน
Fucharoen, Suthat
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Winichagoon, Pranee
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Pootrakul, Pensri
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Wasi, Prawase
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หัวเรื่อง
Genetics (clinical)
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Thalassemia
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บทคัดย่อ
The degree of anemia in β°-thalassemia/hemoglobin E disease is highly variable. As part of an attempt to identify determinants of this variability of severity we studied concordance and discordance of hemoglobin levels among sib pairs. The distribution of differences of hemoglobin levels in 216 sib pairs from 98 families showed a remarkable skewness toward the lower values with a mode at 0-0.5 gm/dl. The prevailing concordance of hemoglobin levels in patients from the same families and the persistence of the patterns indicate that polygenic factors are mainly responsible for the variability of anemia in this disease.
ผู้ร่วมงาน
Thalassemia Center, Faculty of Graduate Studies and Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
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Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-05-02
ประเภท
Article
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รูปแบบ
ขนาดหรือจำนวนของเอกสาร
6 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
American Journal of Medical Genetics ; volume 19, issue 1, page 39-44
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รหัส หรือตัวบ่งชี้เอกสาร
ขอบเขต
เจ้าของลิขสิทธิ์
John Wiley & Sons, Inc.
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