Morphology and Kinetics of Erythropoiesis in Haemoglobin H Disease

ชื่อเรื่อง

Morphology and Kinetics of Erythropoiesis in Haemoglobin H Disease See all items with this value

ผู้สร้าง/เจ้าของผลงาน

Wickramasinghe, S. N.
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Hughes, Madeleine
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Wasi, Prawase
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Fucharoen, Suthat See all items with this value

หัวเรื่อง

Hematology See all items with this value

คำอธิบายรายละเอียดของเอกสาร

This work was supported by a project grant (G979/92/S) from the Medical Research Council and a travel grant to S.N.W. from the British Council. The work done in Thailand was supported by a U.S. Public Health research grant (AM 09805) from the National Institute of Arthritis, Metabolism and Digestive Diseases.

บทคัดย่อ

Some aspects of erythroblast function have been investigated in two Thai patients with haemoglobin H disease. Electron microscope and high resolution autoradiographic studies revealed that (1) some erythroblasts and marrow reticulocytes contained branching intracytoplasmic inclusions and (2) the presence of such inclusions did not necessarily prevent the entry of cells either from the G1 phase into the S phase or from the G2 phase into mitosis. The distribution of early polychromatic erythroblasts in the different stages of the cell cycle was determined by the technique of combined Feulgen microspectrophotometry and 3H-thymidine autoradiography and found to be essentially normal. It is concluded that although the presence of an excess of α-chains in the β-thalassaemia syndromes has been previously shown to be associated with a gross impairment of erythroblast proliferation, the presence of an excess of β-chains in HbH disease is not.

ผู้ร่วมงาน

Department of Haematology, St Mary's Hospital Medical School, University of London See all items with this value

Division of Haematology, Department of Medicine, Siriraj Hospital, Bangkok, Thailand See all items with this value

ปีที่ผลิตเอกสาร

1981 See all items with this value

วันที่บันทึกข้อมูล

2023-05-02

ประเภท

Article See all items with this value

รูปแบบ

pdf See all items with this value

ขนาดหรือจำนวนของเอกสาร

5 pages

ต้นฉบับ/แหล่งที่มาของเอกสาร

British Journal of Haematology ; volume 49, issue 2, page 185-188

ภาษา

en See all items with this value

รหัส หรือตัวบ่งชี้เอกสาร

https://doi.org/10.1111/j.1365-2141.1981.tb07214.x See all items with this value

ขอบเขต

Health See all items with this value

เจ้าของลิขสิทธิ์

John Wiley & Sons, Inc. See all items with this value

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