Ineffective Erythropoiesis in Haemoglobin Eβ -thalassaemia: an Electron Microscope Study
ชื่อเรื่อง
Ineffective Erythropoiesis in Haemoglobin Eβ -thalassaemia: an Electron Microscope Study
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ผู้สร้าง/เจ้าของผลงาน
Wickramasinghe, S. N.
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Hughes, Madeleine
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Wasi, Prawase
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Fucharoen, Suthat
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Modell, Berandette
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หัวเรื่อง
Hematology
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คำอธิบายรายละเอียดของเอกสาร
This work was supported by project grant no. G979/92/S from the Medical Research Council and a travel grant to S.N.W. from the British Council
บทคัดย่อ
Electron microscope studies have been performed on the bone marrow cells of two non-splenectomized patients and the circulating erythroblasts and reticulocytes of three splenectomized patients with HbE/β-thalassaemia. Some intracellular precipitates (probably consisting of α-chains) and mild dyserythropoietic changes were found in the early polychromatic erythroblasts within the bone marrow. Larger quantities of precipitate and more marked dyserythropoietic changes were found in the late polychromatic erythroblasts and reticulocytes both within the marrow and within the circulation. The bone marrow macrophages contained phagocytosed erythroblasts within their cytoplasm. These data indicate that the anaemia in HbE/β-thalassaemia results largely from dyserythropoiesis and ineffective erythropoiesis. The ultrastructural abnormalities encountered in the cases of HbE/β-thalassaemia were qualitatively and quantitatively similar to those seen in homozygous β-thalassaemia.
ผู้ร่วมงาน
Department of Haematology, St Mary's Hospital Medical School, University of London, England
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Division of Haematology, Department of Medicine, Siriraj Hospital, Bangkok, Thailand
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Departments of Obstetrics and Paediatrics, University College Hospital Medical School, University of London, England
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-05-02
ประเภท
Article
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ขนาดหรือจำนวนของเอกสาร
9 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
British Journal of Haematology, Vol. 48, Page 451-457.
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เจ้าของลิขสิทธิ์
John Wiley & Sons, Inc.
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