Haemoglobin synthesis in 28 obligatory cases for α-thalassemia traits

ชื่อเรื่อง

Haemoglobin synthesis in 28 obligatory cases for α-thalassemia traits See all items with this value

ผู้สร้าง/เจ้าของผลงาน

Pootrakul, Sa-nga See all items with this value

Sapprapa, Suwat See all items with this value

Wasi, Prawase See all items with this value

Na-Nakorn, Supa See all items with this value

Suwanik, Romsai See all items with this value

หัวเรื่อง

Haemoglobin See all items with this value

Thalassemia See all items with this value

บทคัดย่อ

In the Far East two types of α-thalassemia genes, namely α-thalassemia1 (α-thal1) and α-thalassemia2 (α-thal2) exist. Definite diagnosis of the α-thal1 and α-thal2 traits is very difficult because their hematological findings are minimally abnormal or normal. This study attempts to characterize the heterozygotes by hemoglobin chain synthesis in reticulocytes from obligatory cases of the α-thal1 and α-thal2 traits. Twelve parents of babies with hemoglobin Bart's hydrops fetalis (obligatory α-thal1 trait) had the mean total radioactivity α/β ratio of 0.76±SD 0.04, while that of 7 normal controls was 1.06±SD 0.04. The α/β globin chain ratios of 16 cases, who were either parents or offspring of patients with hemoglobin H disease, were found to segregate into 2 groups, i.e. 0.78±SD 0.03 (10 cases) and 0.92±SD 0.03 (6 cases), probably representing the α-thal1 and α-thal2 traits respectively. The hematological data of the first group showed definite hypochromic microcytic red cells, similar to thoseof the parents of the hydrops. The second group had significantly higher mean corpuscular hemoglobin than the first group, compatible with α-thal2 trait. Our globin chain synthesis study thus appears to be capable of discriminating normal, α-thal1 and α-thal2 traits.

ผู้ร่วมงาน

Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand See all items with this value

Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand See all items with this value

ปีที่ผลิตเอกสาร

1975 See all items with this value

วันที่บันทึกข้อมูล

2023-05-01

ประเภท

Article See all items with this value

รูปแบบ

pdf See all items with this value

ขนาดหรือจำนวนของเอกสาร

6 pages

ต้นฉบับ/แหล่งที่มาของเอกสาร

Humangenetik, Vol. 29, Page 121–126

ภาษา

en See all items with this value

รหัส หรือตัวบ่งชี้เอกสาร

https://doi.org/10.1007/BF00430348 See all items with this value

ขอบเขต

Health See all items with this value

เจ้าของลิขสิทธิ์

Springer Nature Switzerland AG. Part of Springer Nature See all items with this value

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