Is The Human Globin α-Chain Locus Duplicated?
ชื่อเรื่อง
Is The Human Globin α-Chain Locus Duplicated?
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ผู้สร้าง/เจ้าของผลงาน
Wasi, Prawase
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หัวเรื่อง
Hematology
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บทคัดย่อ
The normal human adult has at least three types of haemoglobin, namely A, F and Az. The globin moiety of haemoglobin (Hb) A consists of two a-chains and two 8-chains. Hb A is thus ct2B2, whereas Hb F is a,y, and Hb A, is az6,. The a-chain consists of 141 amino acid residues, while each of the three non-alpha chains has 146 amino acid residues. The primary structures ofthe a, p, y and S chains have been completely worked out. Synthesis ofthese four types of polypeptide chains is directed by separate structural genes and their quantities are precisely controlled. Structural haemoglobin variants occur mostly from single amino acid substitutions in any of the globin peptide chains. Much less commonly structural variants occur from other mechanisms such as unequal crossing-over and gene deletion. Thalassaemia is a group of genetic defects primarily leading to decreased synthesis of any of the peptide chains. Although y- and 6-thalassaemias are recognized, a- and p-thalassaemias have been better examined (see reviews by Huehns, 1965; Lehmann et al, 1966; Weatherall & Clegg, 1972).
ผู้ร่วมงาน
Faculty of Medicine, Siriraj Hospital, Mahidol University
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-05-01
ประเภท
Article
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รูปแบบ
ขนาดหรือจำนวนของเอกสาร
7 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
British Journal of Haematology, Vol 24, Page 267-273.
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ขอบเขต
เจ้าของลิขสิทธิ์
John Wiley & Sons, Inc.
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