The Pattern of Disordered Haemoglobin Synthesis in Homozygous and Heterozygous β-Thalassaemia
ชื่อเรื่อง
The Pattern of Disordered Haemoglobin Synthesis in Homozygous and Heterozygous β-Thalassaemia
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ผู้สร้าง/เจ้าของผลงาน
Weatherall, D. J.
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Clegg, J. B.
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Na-Nakorn, Supa
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Wasi, Prawase
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หัวเรื่อง
Haematology
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Thalassaemia
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คำอธิบายรายละเอียดของเอกสาร
This article was presented in part at the meeting of the British Society for Haematology, Newcastle, 1968.
บทคัดย่อ
The rate of globin chain production has been studied in patients with homozygous β-thalassaemia, heterozygous β-thalassaemia, haemoglobin E-thalassaemia, and sickle-cell-thalassaemia, and compared with that in non-thalassaemic individuals. A partial or total deficit of β-chain synthesis has been demonstrated in all forms of β-thalassaemia. This results in the production of a large intracellular pool of α-chains, the kinetics of which have been worked out. The α-chains in this pool appear to contain haem and are unstable, rapidly becoming associated with the stromal fraction. These findings are examined in terms of the pathogenesis of the anaemia of thalassaemia.
ผู้ร่วมงาน
Nuffield Unit of Medical Genetics, Department of Medicine, University of Liverpool
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Haematology Division, Siriraj Hospital, Bangkok
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-04-28
ประเภท
Article
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รูปแบบ
ขนาดหรือจำนวนของเอกสาร
17 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
British Journal of Haematology, Vol. 16, Page 251-268
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ขอบเขต
เจ้าของลิขสิทธิ์
John Wiley & Sons, Inc.
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