The Thai variant and the distribution of alleles of 6-phosphogluconate dehydrogenase and the distribution of glucose 6-phosphate dehydrogenase deficiency in Thailand
ชื่อเรื่อง
The Thai variant and the distribution of alleles of 6-phosphogluconate dehydrogenase and the distribution of glucose 6-phosphate dehydrogenase deficiency in Thailand
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ผู้สร้าง/เจ้าของผลงาน
Tuchinda, Soodsarkorn
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Rucknagel, Donald L.
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Na-Nakorn, Supa
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Wasi, Prawase
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หัวเรื่อง
Genetics
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Molecular Biology
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General Medicine
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Ecology, Evolution, Behavior and Systematics
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Biochemistry
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คำอธิบายรายละเอียดของเอกสาร
This article was supported by U.S. Army Contract DA-49-193 MD 2879, U.S.P.H.S. GM 09252, and U.S.P.H.S. 5-K3-GM-15325.
บทคัดย่อ
The samples were taken from 3185 subjects from ten provinces throughout Thailand. In 1577 males the frequency of glucose 6-phosphate dehydrogenase deficiency was 11.98%. In the far south the gene frequency was 2.83%; in the remainder of the country the frequency did not vary significantly about a mean of 13.76%. The deficiency is of a severe type. The G6PD of all of the nondeficient individuals had the electrophoretic mobility of type B. The mean frequency of the A/B electrophoretic phenotype of 6-phosphogluconate dehydrogenase is 8.47%. The maximum frequency was in central and southern Thailand with a decline to the north and northeast. A variant form of 6-PGD, referred to as the Thai variant, has been found in which two additional electrophoretic components migrate anodally to the normal A band, confirming that the molecule is at least a dimer. The hypothesis is advanced that erythrocyte 6-PGD is determined by two genetic loci, only one of which is translated in leukocytes
ผู้ร่วมงาน
Department of Pediatrics, Siriraj Hospital, Bangkok, Thailand
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Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Department of Internal Medicine, Siriraj Hospital, Bangkok, Thailand
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ปีที่ผลิตเอกสาร
วันที่บันทึกข้อมูล
2023-04-27
ประเภท
Article
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รูปแบบ
ขนาดหรือจำนวนของเอกสาร
12 pages
ต้นฉบับ/แหล่งที่มาของเอกสาร
Biochemical Genetics, Volume2, Page 253–264
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รหัส หรือตัวบ่งชี้เอกสาร
ขอบเขต
เจ้าของลิขสิทธิ์
Springer Nature Switzerland AG. Part of Springer Nature.
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